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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '781b0e063e7d2dae95ab1c137bc417e91a10899a144b2a057991f75b135a5050' 
  AND token = 'JdYx2M28iS4Zkbt/UeMZMEMuPj9FNPY/083DwPcmkOw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}