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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '168295a6cab1721990e2ac12eff798acc006677ec88dfe7b8af69c45e0cc3871' 
  AND token = '6IwdRgXR7+DvzDrwkIiQA6/AKrpi8c/T4J9HlbkyKGA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}