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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52c1dcd415bb48f40eaf0bb0140f28728b4107df0bcf2f81e59e309dceab507f' 
  AND token = 'w7+TmTeyyt6h7iRE5Ne3mZ//CRB5MAwICyfeLU80dl8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}