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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52749d6ffcebbfed5964933a0d9a5f78ebc269d657a8d3275eb1ebc5bac507b3' 
  AND token = 'gMWOGWtby6P4aWg1JSwmzkTYBtp50dRowJ8zB/CAhbk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}