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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c1b91f0fcb0c5b03b7fce2df9ef2d82622b203167cd022d483a91f8b1a33454' 
  AND token = 'iV1xbCdW6NeIbvhzTwan3jqvMw0mCyQ0XpXh458lCxQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}