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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5a6ee88e4f0cd3706ba4fc3a247b8aabf127def28a4d72cd471a2debe7040ec2' 
  AND token = 'njRjtTSUjRp82I8fcdncAVs1Uzc5QTLuzyUx+omHdbQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}