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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3e4727af265d38d8236d2771f0daa5dfe0b4edb477c305966d5e5e1fbca41440' 
  AND token = 'IIoWRYKSCthYd+2e94EwVEZytTOEsL7i8aMHCWrtLSU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00038

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}