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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8499e7bf80bdea72475fa18002e93b6a6951af09b6ade29d3ba95e20211c6b51' 
  AND token = 'tTnBeLN7HrZXCwYsddY1dOYKZv2qPfIU8CZYY3MXuaA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00047

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}