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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8296908c388b9c8aa1c1288330584eb5b1bc92696d63021e6dcad7d81582578a' 
  AND token = 'VQkaTuwn8d3tbFgWFpKDo78O/K0wxfH9tQgzTn0mNiQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}