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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7fdb33503e23b2f1f31113740749835af58b34cb44dbdda2e2397361e0c05869' 
  AND token = '2FsuzeL0G8Az0Xozo3FFXFN+rqYQR0bRCCXFIcF1jvg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}