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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9f75079b7e52308081d6644ee9de587f6610026f9904da29aaaca54d38843619' 
  AND token = 'rjo/rDUW0RY1cWS3h/pDt0TeCwNYyftdXfq4JxRTPjg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}