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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7c6b80466ef69b49fea5fc292b1e07234d10fed6a8079e7a8b0d80f945b73914' 
  AND token = 'Oo6CjlTBCS1wUSr1s3s0GAQH2Ib2lYUDkJYiRbfq7uM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}