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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '24486d3ec30c5e07129ba4503c480a09acf2d1edcb93a82fe06fd7d4f99c8051' 
  AND token = 'JHFSfAsuk8RfiK0UjhW6FNzrtXm36L8JZeilt7mP+ZM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}