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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a143ee220e5d5d236fbd41f5e6e3370d0c35d9344ffb32a54d504e602b458478' 
  AND token = 'PA/QTLTNn6OHsvam3wqGMfyaM7Fo/v0HK5NUtxXzKAA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}