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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'acd75aa20d45b4306fdd292c8e7a3b306e526c53054350885a3c9f4504d07c18' 
  AND token = 'eNrZqvM5jV7AVgK7qSGodZ03rHZBoTI+Ol6ZRGfAyt0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}