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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4c42e80f9f124c6a5fe152d4e1581a1bb7e02532afeaf9fbad68edc84b9031d' 
  AND token = '+C48x6mMY5Gvjaf+5y0dcV8QpteZwS+pTx5qaeEiHRM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}