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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22dbc978392b8602d2afde2cfc95ce06707c8224a1d4360aa02a31b4a84259c1' 
  AND token = 'WnGFuI780VDcRjhcUmmOFrtaEh9AqV1HmzCXTZM0aDg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}