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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49183ac0c68df4f033a50082bda58aaeeefee60a6723cd4a7bd3fcaa20e28c3c' 
  AND token = 'skPDW1AZgZBYILxtZGJTAAolEQ8KH6anWQ0eJa3HXYA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}