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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '019c1296769458eb2daa166cfdaeca1dd47ee7d08ab666bc7721c06d2b4c9354' 
  AND token = 'VkGREhPRh8WWen+wjpeeW9d1YmnfE8sYtOgnMDWnWm8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}