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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3d8f18aa580bdbab4e11f95f136c2c37976da3b611d41f5406384390a5ba1461' 
  AND token = '7jjnHi17xmQnGHUwmic902VM+dkFh29bybeP6+UOzYs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}