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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21382d219f623d6a72a853844ca4620f1aa3d278d70c2385dc95da4ae8ddbf7f' 
  AND token = 'Pd+oNa8q4/zlqeYuQH6Ba5EBzB9ccJZEgPJeDBbc340=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}