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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '501549a0aaaa28189dc1d6eb19b51eed17f678c68bf70d5e8d382349d51d8242' 
  AND token = 'rADXirUS5hBgKACYECpchq34QmbIUa8jx2b0vqSGImY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}