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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af3a4629970e78722fa86dee5a8ec9702cb2cde5803fdde61459b1b21d06c0f2' 
  AND token = 'nfpupT1SFytygtxRiWdTEYqKebCAPMYh/FPCgt649s0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}