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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '220a4fae2697a8b67c59c7512eecc99e0e8ccae83289ddb05756bc3e5c024496' 
  AND token = 'w2g4kqt2Jh195rVo0xGB+Sha8cv7hnYi0NaSf9JXTt0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}