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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50e66c121a2b4bf9a566808e7937505feba162237f91e286a1fc8ed74954fe90' 
  AND token = 'TZs4/p7jFERWKgEn/x4j8rIfZ9o43LJ1RMqWzog3Y3Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}