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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49d03da6902c07681b0fd35a85e28d5d6fb646642369e95206f332abde893888' 
  AND token = 'iApqFm71srh2ZuFd1YO+am3oO1S66I3uBK4eL1ktknw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}