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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'aa5df269f611a2e80f612653e41d730927f05588ecf4d0e80e43f72bae664991' 
  AND token = 'lv8EaSoZHNWSYF5R9EATmnR8NVaQpk8QkZhPx0ZXblk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}