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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8250d71b56bb6520b3e4302a3ed729afb6b7d33db34d7acf57642874ea194cb2' 
  AND token = 't/05/1JRiPSxLjzPN368WJPS263/gXpBbHpgWw/gZMo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}