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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0b0203a46b321c9ccb939a47485f811e5063dcdeaf2258fa960223d9f7195ef4' 
  AND token = 'FpVmDikLkhop6sWTZdaS5LP0jcv576aD4nWTtn9FCAQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}