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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '67287838758d6a6f5c62eaf756ee385f0970e499d9c968fe2dc17b0e8ee33372' 
  AND token = 'Pgz+BoL4uPqR2oF6hIaXkiBV9LdB+FSj28iSnEMjFs0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}