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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0e1609859f4d644969a755493d50749320ab9b52410aa4f268bbdc9654450b26' 
  AND token = 'uCFImV/QYuUk5TF6Xu/t0BIAfnkqOa5bHGKcWqDDqtU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}