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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '33df5e48b34de4b3ca16bbb36d32a34f38c36eeb5ff732c370db8356153b87af' 
  AND token = 'MwqR3/p4skFEj12y02zGyWM0/+SxnTSb8NJ2mZp6GqY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00041

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}