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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '300af89a3e629762413dd89335a887a02cb20a716b2d15137ac1c677a3735428' 
  AND token = 'JAxQ0aYceN1SwOcLmZE5cQ00TFOR7hwUfNA8xbcDWoo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}