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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7e4ea212e92429858e127994b0f0bdfc593730559c135fc87f5e02014a59cd30' 
  AND token = 'iddwrjZzBlv6WHHoIwtMhDpKSdmxWvmpQ1R8yQivsag=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}