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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9c529fe8682483de5942c79ba46ea8368cd022127b2bd9f5032e01af82bc3809' 
  AND token = '19CUU3ij6rW589L1zQROnGiowajQHpqYmol9HJEiVJc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}