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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25ffa0e342ea6598ec51bd755489cf7c985192f4df525567cad6e855d8f274c6' 
  AND token = 'du2Cu0BtZ3Iwuosxis+QS6m4O0Sl2vBVEMeOUgRXVj4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}