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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c6af00f3d1802ed8901f249f6184862dde220227366410bd5d5f4379178ec50b' 
  AND token = 'E2UAakwKmqe6jqdOET/WzoXhk6YrKU7XhbWgV8EWIMQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}