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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f0f157ddff1a5d5af712ec2f55539dd3640d79f09746ced1e3174afad25854ec' 
  AND token = 'VCNimoQ1SNxx3GYzY+mVcCAC3RIH5X+5ceMXKAxk7nc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}