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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '497d90ec69915ca28256edba00ceb70128c16718f638f790d99044a88e1580be' 
  AND token = 'cJS1SLO88+FC7fzEWktKK6DL4/f7m98GhAVDCzwt5r8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}