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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a2238252e09dc2d1d06caa6e50c58e73afa245e11154c138f1ecd6023171bc2c' 
  AND token = '4D6Dep9lROmPqhsBx7xD606VrKIgcNDsdGDVPKpaHhg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}