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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1235025de79bb18cc67444c570c9fc17dfd87bed7e236195dc9fd2e82de2bf8c' 
  AND token = 'srdOQ9ElQ/eSzptZlF8/+leEgWr2+nUIvcBkfN5Oxhc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}