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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22ee18ae6b0c211e1873954df23729e11324343af5589975b2b1c4f0d5415c61' 
  AND token = 'zhRq/JJ8+teLanHUZ3C2rysY//OyyfbPii4NnQc4svw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}