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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '222cc2e53880de3bd6d78fa654d86437f97b70b105633552a50eaac646b01104' 
  AND token = 'Sjezo08/6K35/n2BeLhP93v6x1uuUY7bsPCVr7mMm2M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}