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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '496161042a898db52324c18e4a2df778b8c6419f9bf1138263d3aa57f1aa36f7' 
  AND token = '2xY8FareXBNKEcpEo0800YcY1uflMkRdVXgk1MhAR5k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}