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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '281f8b554dc66b6e5e21d1f80fab099782bba06d496d10a7a5c3099b3aca5a8d' 
  AND token = '/jN2ZXSmhFfWKVKHxNmPaZaqnG1VX0nqVqnS0mGC3M0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}