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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e486f013fccc502fb08a42d590b173be772c09b24a0ecaf3fcf7e9d39c53a5ab' 
  AND token = 'Rs81/wDPAfOhAbePm0DYMS8DUnUPomQ/YbeVNu85zX8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}