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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49f4535046018ab73dd466722e36619af96153038c98229e9341170fe0de6400' 
  AND token = 't3Po5LxHdYnKEQXhhAA7NSqRTd3QEMyfQ6cEeWI5XIE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}