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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd2dfcfdcf55a898a121cf9852b64a612c11b221ec1bb98b28c6906db7892407b' 
  AND token = 'HNzM4ZARoT9wYTLSdQel4Rs/NnE7/kEduPBjli4Z4vI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}