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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fdef98f5da980c2aa8dc463247e940933052ada2b68339c453c45fb4ef446418' 
  AND token = 'iItSZSt2Ml2kVAg9Oc+Gz5XQFZW7OAlkW5fE5OxbZBY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}