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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '708f72352ed58e3022b2b05c520a2562488b4897586a03b5227e40550e57d6c9' 
  AND token = 'CoGY+lCaKkUYVYeYzLsI3D5pC2HVUp/+jftOq7dc4cs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}